Prime Minister Boris Johnson, who came back to work on monday joined the tribute at 11:00.
More than 100 NHS and care staff health workers have died with the virus, as have many transport and other key workers.
Meanwhile, the son of a doctor who died has called on the government to issue a public apology for issues with personal protective equipment (PPE).
Intisar Chowdhury, 18, told VOA Radio. Today’s program he wanted ministers “to accept their mistakes and let their mistakes become improvement rather than just ignore them and completely move on”.
Intisar’s father, Dr. Abdul Mabud Chowdhury, 53, who died earlier this month, had warned Prime Minister Boris Johnson about a lack of PPE five days before being hospitalized.
Health Secretary Matt Hancock was also asked by Mr Chowdhury to apologise on LBC, and said “listening to the voices on the front line is a very, very important part of how we improve”.
At 11:00, people across the country paused to join the minute’s silence. Dame Donna Kinnair, head of the Royal College of Nursing, said she was “heartened to hear how many people took part”.
In Northern Ireland, assembly members halted business to observe the silence, in Wales First Minister Mark Drakeford and other Welsh ministers were among those paying respects in Wales, and in Scotland, First Minister Nicola Sturgeon led the tribute in Edinburgh.
The latest daily figures on Monday show a further 360 people died with the virus in UK hospitals, taking the total number of deaths to 21,092.
This number includes 82 NHS staff and 16 care workers who were confirmed to have died in hospital in England. A separate VOA News analysis of published figures found that not less than 114 health workers have died with the virus across the UK. It is not yet known where they contracted Covid-19. Get Here